Cargando…

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes

Direct reprogramming of fibroblasts into cardiomyocytes is a promising approach for cardiac regeneration but still faces challenges in efficiently generating mature cardiomyocytes. Systematic optimization of reprogramming protocols requires scalable, objective methods to assess cellular phenotype be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sutcliffe, Matthew D., Tan, Philip M., Fernandez-Perez, Antonio, Nam, Young-Jae, Munshi, Nikhil V., Saucerman, Jeffrey J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775342/ https://www.ncbi.nlm.nih.gov/pubmed/29352247 http://dx.doi.org/10.1038/s41598-018-19539-z

Ejemplares similares

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling
por: Tan, Philip M., et al.
Publicado: (2017)

Direct reprogramming of fibroblasts into cardiomyocytes
por: Chen, Yueqiu, et al.
Publicado: (2017)

Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming
por: Fernandez-Perez, Antonio, et al.
Publicado: (2019)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
por: Ishida, Tomoaki, et al.
Publicado: (2021)

Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair
por: Elia, Andrea, et al.
Publicado: (2023)

Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming
por: Zhang, Zhentao, et al.
Publicado: (2019)

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
por: Qian, Li, et al.
Publicado: (2012)

From fibroblast cells to cardiomyocytes: direct lineage reprogramming
por: Yang, Lei
Publicado: (2011)

Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails
por: Fu, Yanbin, et al.
Publicado: (2015)

The MEK/ERK Module Is Reprogrammed in Remodeling Adult Cardiomyocytes
por: Thomas, Kubin, et al.
Publicado: (2020)

Direct Cardiac Reprogramming　― Converting Cardiac Fibroblasts to Cardiomyocytes ―
por: Sadahiro, Taketaro
Publicado: (2019)

Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state
por: Kisby, Thomas, et al.
Publicado: (2021)

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells
por: Prodan, Nicole, et al.
Publicado: (2022)

Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
por: Zhang, Yiqiang, et al.
Publicado: (2015)

Impact of Biomaterials on Differentiation and Reprogramming Approaches for the Generation of Functional Cardiomyocytes
por: Paoletti, Camilla, et al.
Publicado: (2018)

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons
por: Chuang, Wenpo, et al.
Publicado: (2017)

OSKM-mediated reversible reprogramming of cardiomyocytes regenerates injured myocardium
por: Farber, Gregory, et al.
Publicado: (2022)

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts
por: Nelson, Anders R., et al.
Publicado: (2023)

UniqTag: Content-Derived Unique and Stable Identifiers for Gene Annotation
por: Jackman, Shaun D., et al.
Publicado: (2015)

Comparative functional genomics identifies unique molecular features of EPSCs
por: Malik, Vikas, et al.
Publicado: (2022)

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State
por: Fu, Ji-Dong, et al.
Publicado: (2013)

Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration
por: Cheng, Yuan‐Yuan, et al.
Publicado: (2016)

Corrigendum: Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
por: Zhang, Yiqiang, et al.
Publicado: (2017)

Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes
por: Paoletti, Camilla, et al.
Publicado: (2021)

Ultraefficient extracellular vesicle–guided direct reprogramming of fibroblasts into functional cardiomyocytes
por: Kim, Hyosuk, et al.
Publicado: (2022)

Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
por: Khalilimeybodi, Ali, et al.
Publicado: (2020)

CHD-associated enhancers shape human cardiomyocyte lineage commitment
por: Armendariz, Daniel A, et al.
Publicado: (2023)

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition
por: Bhattacharyya, Samadrita, et al.
Publicado: (2019)

Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells
por: Palazzolo, Giacomo, et al.
Publicado: (2016)

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog
por: Wang, Xiaowen, et al.
Publicado: (2016)

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling
por: Zhao, Yuanbiao, et al.
Publicado: (2015)

Single-cell transcriptome and epigenomic reprogramming of cardiomyocyte-derived cardiac progenitor cells
por: Chen, Xin, et al.
Publicado: (2016)

OCT4 expression mediates partial cardiomyocyte reprogramming of mesenchymal stromal cells
por: Yannarelli, Gustavo, et al.
Publicado: (2017)

Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming
por: Sadahiro, Taketaro
Publicado: (2019)

Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming
por: Singh, Vivek P., et al.
Publicado: (2021)

Detecting red-lesions from retinal fundus images using unique morphological features
por: Monemian, Maryam, et al.
Publicado: (2023)

Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming
por: Jin, Wensong, et al.
Publicado: (2016)

Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells
por: Velasquez-Mao, Aaron J., et al.
Publicado: (2017)

Author Correction: Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition
por: Bhattacharyya, Samadrita, et al.
Publicado: (2020)

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming
por: Liu, Dawei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h1si6n82hdisur8emgsgoqnpbe