Cargando…

Binding of α(v)β(3) Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

PURPOSE: Molecular imaging of α(v)β(3) integrin has exhibited real potential to guide the appropriate use of anti-angiogenic therapies. However, an incomplete understanding of the factors that influence binding of α(v)β(3) integrin-specific radiotracers currently limits their use for assessing respo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andriu, Alexandra, Crockett, Julie, Dall’Angelo, Sergio, Piras, Monica, Zanda, Matteo, Fleming, Ian N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775384/ https://www.ncbi.nlm.nih.gov/pubmed/28695371 http://dx.doi.org/10.1007/s11307-017-1100-z

Ejemplares similares

First-in-human pilot study of an integrin α6-targeted radiotracer for SPECT imaging of breast cancer
por: Gao, Shi, et al.
Publicado: (2020)

H-CRRETAWAC-OH, a Lead Structure for the Development of Radiotracer Targeting Integrin α (5) β (1)?
por: Haubner, Roland, et al.
Publicado: (2014)

Clinical value of 3'-deoxy-3'-[(18)F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
por: Alwadani, Bandar, et al.
Publicado: (2021)

Clustering in integrin binding
por: Tuma, Rabiya
Publicado: (2004)

Structural Basis for the Activation of Platelet Integrin αIIbβ3 by Calcium- and Integrin-Binding Protein 1
por: Huang, Hao, et al.
Publicado: (2012)

Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits
por: Nishimichi, Norihisa, et al.
Publicado: (2015)

Integrins
por: Barczyk, Malgorzata, et al.
Publicado: (2009)

Binding a bent integrin
por: LeBrasseur, Nicole
Publicado: (2005)

Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway
por: Rintanen, Nina, et al.
Publicado: (2012)

“INTEGRINating” the connexin hemichannel function in bone osteocytes through the action of integrin α5
por: Batra, Nidhi, et al.
Publicado: (2012)

Integrin α(v)β(3)-Targeted Radiotracer (99m)Tc-3P-RGD(2) Useful for Noninvasive Monitoring of Breast Tumor Response to Antiangiogenic Linifanib Therapy but not Anti-Integrin α(v)β(3) RGD(2) Therapy
por: Ji, Shundong, et al.
Publicado: (2013)

Preclinical Evaluation of [(18)F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters
por: Testa, Andrea, et al.
Publicado: (2018)

Endocytosis of Integrin-Binding Human Picornaviruses
por: Merilahti, Pirjo, et al.
Publicado: (2012)

A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8
por: Le, Viet Q., et al.
Publicado: (2023)

Structure and Binding Interface of the Cytosolic Tails of αXβ2 Integrin
por: Chua, Geok-Lin, et al.
Publicado: (2012)

Distinct Binding Interactions of α(5)β(1)-Integrin and Proteoglycans with Fibronectin
por: Kennelly, Thomas M., et al.
Publicado: (2019)

Binding of the protein ICln to α-integrin contributes to the activation of ICl(swell) current
por: Schedlbauer, Andreas, et al.
Publicado: (2019)

Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
por: Hernandez‐Gerez, Elena, et al.
Publicado: (2020)

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
por: Bharadwaj, Mitasha, et al.
Publicado: (2017)

The integrins
por: Takada, Yoshikazu, et al.
Publicado: (2007)

Mena binds α5 integrin directly and modulates α5β1 function
por: Gupton, Stephanie L., et al.
Publicado: (2012)

(18)F-FP-PEG(2)-β-Glu-RGD(2): A Symmetric Integrin α(v)β(3)-Targeting Radiotracer for Tumor PET Imaging
por: Hu, Kongzhen, et al.
Publicado: (2015)

Integrin α1 subunit is up-regulated in colorectal cancer
por: Boudjadi, Salah, et al.
Publicado: (2013)

Optimized serum stability and specificity of an αvβ6 integrin-binding peptide for tumor targeting
por: Cardle, Ian I., et al.
Publicado: (2021)

A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion
por: Tucker, Katherine L., et al.
Publicado: (2008)

The Integrin-Linked Kinase-PINCH-Parvin Complex Supports Integrin αIIbβ3 Activation
por: Honda, Shigenori, et al.
Publicado: (2013)

The membrane-distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activation
por: Thinn, Aye Myat Myat, et al.
Publicado: (2018)

DGK-α keeps integrins close to the edge
por: Mitch, Leslie
Publicado: (2012)

Integrin α(V)β(3) can substitute for collagen‐binding β(1)‐integrins in vivo to maintain a homeostatic interstitial fluid pressure
por: Lidén, Åsa, et al.
Publicado: (2018)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

Structural Determinants of Integrin Binding to the Talin Rod
por: Gingras, Alexandre R., et al.
Publicado: (2009)

Erratum to “Endocytosis of Integrin-Binding Human Picornaviruses”
por: Merilahti, Pirjo, et al.
Publicado: (2013)

RGD-Binding Integrins in Head and Neck Cancers
por: Ahmedah, Hanadi Talal, et al.
Publicado: (2017)

Regulation of α5β1 integrin conformation and function by urokinase receptor binding
por: Wei, Ying, et al.
Publicado: (2005)

Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding
por: Yigit, Sezin, et al.
Publicado: (2016)

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
por: Xu, Xiaohong Ruby, et al.
Publicado: (2018)

Galectin-3 Binding to α(5)β(1) Integrin in Pore Suspended Biomembranes
por: Sarangi, Nirod Kumar, et al.
Publicado: (2022)

Regulation of Dynamic Cell Adhesion by Integrin-Integrin Crosstalk
por: Gahmberg, Carl G., et al.
Publicado: (2022)

Affinity Modulation of Platelet Integrin α(IIb)β(3) by β(3)-Endonexin, a Selective Binding Partner of the β(3) Integrin Cytoplasmic Tail
por: Kashiwagi, Hirokazu, et al.
Publicado: (1997)

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension
por: Cormier, Anthony, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5k4s1f6u7t1nsaqa4u5bdjnbi3