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A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population

BACKGROUND: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N–acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a geno...

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Autores principales: Yang, Bo, Yan, Shan, Yan, Jianjun, Li, Yafei, Khurwolah, Mohammad Reeaze, Wang, Liansheng, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775593/
https://www.ncbi.nlm.nih.gov/pubmed/29351739
http://dx.doi.org/10.1186/s12872-018-0743-2
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author Yang, Bo
Yan, Shan
Yan, Jianjun
Li, Yafei
Khurwolah, Mohammad Reeaze
Wang, Liansheng
Chen, Zhong
author_facet Yang, Bo
Yan, Shan
Yan, Jianjun
Li, Yafei
Khurwolah, Mohammad Reeaze
Wang, Liansheng
Chen, Zhong
author_sort Yang, Bo
collection PubMed
description BACKGROUND: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N–acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. Because IMT is a potent marker of coronary artery disease (CAD), the aim of this study was to evaluate the relation of rs12040273 to susceptibility and severity of CAD in a Chinese Han population. METHODS: We performed a hospital-based case-control study. Three hundred and thirty-one individuals (199 CAD patients and 112 non-CAD controls) undergoing coronary angiography were consecutively enrolled in the study. The Gensini score results were used to assess the severity of CAD. The method of polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to distinguish different genotypes at rs12040273. RESULTS: The distribution of genotypes at rs12040273 was comparable between CAD patients and non-CAD controls (P > 0.05). The frequencies of the genotypes were also not significantly associated with the risk of CAD and its severity assessed by the Gensini score method, with the OR of 1.38 (95% CI = 0.80–2.40, P = 0.24) and 1.14 (95% CI = 0.69–1.86, P = 0.60) respectively. However, stratified analysis showed that the serum HDL-C levels of subjects with the CC genotype were significantly higher than those with CT/TT genotypes in non-CAD controls (P = 0.002). CONCLUSION: Our results suggest that the rs12040273 variants might not be associated with the susceptibility of CAD or its severity in a Chinese Han population. Moreover, the CC genotype could be associated with elevated serum HDL-C levels.
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spelling pubmed-57755932018-01-31 A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population Yang, Bo Yan, Shan Yan, Jianjun Li, Yafei Khurwolah, Mohammad Reeaze Wang, Liansheng Chen, Zhong BMC Cardiovasc Disord Research Article BACKGROUND: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N–acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. Because IMT is a potent marker of coronary artery disease (CAD), the aim of this study was to evaluate the relation of rs12040273 to susceptibility and severity of CAD in a Chinese Han population. METHODS: We performed a hospital-based case-control study. Three hundred and thirty-one individuals (199 CAD patients and 112 non-CAD controls) undergoing coronary angiography were consecutively enrolled in the study. The Gensini score results were used to assess the severity of CAD. The method of polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to distinguish different genotypes at rs12040273. RESULTS: The distribution of genotypes at rs12040273 was comparable between CAD patients and non-CAD controls (P > 0.05). The frequencies of the genotypes were also not significantly associated with the risk of CAD and its severity assessed by the Gensini score method, with the OR of 1.38 (95% CI = 0.80–2.40, P = 0.24) and 1.14 (95% CI = 0.69–1.86, P = 0.60) respectively. However, stratified analysis showed that the serum HDL-C levels of subjects with the CC genotype were significantly higher than those with CT/TT genotypes in non-CAD controls (P = 0.002). CONCLUSION: Our results suggest that the rs12040273 variants might not be associated with the susceptibility of CAD or its severity in a Chinese Han population. Moreover, the CC genotype could be associated with elevated serum HDL-C levels. BioMed Central 2018-01-19 /pmc/articles/PMC5775593/ /pubmed/29351739 http://dx.doi.org/10.1186/s12872-018-0743-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yang, Bo
Yan, Shan
Yan, Jianjun
Li, Yafei
Khurwolah, Mohammad Reeaze
Wang, Liansheng
Chen, Zhong
A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title_full A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title_fullStr A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title_full_unstemmed A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title_short A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population
title_sort study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a chinese han population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775593/
https://www.ncbi.nlm.nih.gov/pubmed/29351739
http://dx.doi.org/10.1186/s12872-018-0743-2
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