Ageing: from inflammation to cancer

Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transform...

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Autores principales: Leonardi, Giulia C., Accardi, Giulia, Monastero, Roberto, Nicoletti, Ferdinando, Libra, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775596/
https://www.ncbi.nlm.nih.gov/pubmed/29387133
http://dx.doi.org/10.1186/s12979-017-0112-5
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author Leonardi, Giulia C.
Accardi, Giulia
Monastero, Roberto
Nicoletti, Ferdinando
Libra, Massimo
author_facet Leonardi, Giulia C.
Accardi, Giulia
Monastero, Roberto
Nicoletti, Ferdinando
Libra, Massimo
author_sort Leonardi, Giulia C.
collection PubMed
description Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development.
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spelling pubmed-57755962018-01-31 Ageing: from inflammation to cancer Leonardi, Giulia C. Accardi, Giulia Monastero, Roberto Nicoletti, Ferdinando Libra, Massimo Immun Ageing Review Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development. BioMed Central 2018-01-19 /pmc/articles/PMC5775596/ /pubmed/29387133 http://dx.doi.org/10.1186/s12979-017-0112-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Leonardi, Giulia C.
Accardi, Giulia
Monastero, Roberto
Nicoletti, Ferdinando
Libra, Massimo
Ageing: from inflammation to cancer
title Ageing: from inflammation to cancer
title_full Ageing: from inflammation to cancer
title_fullStr Ageing: from inflammation to cancer
title_full_unstemmed Ageing: from inflammation to cancer
title_short Ageing: from inflammation to cancer
title_sort ageing: from inflammation to cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775596/
https://www.ncbi.nlm.nih.gov/pubmed/29387133
http://dx.doi.org/10.1186/s12979-017-0112-5
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