Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer

The Notch signaling pathway mediates cell fate decisions(1,2) and is tumor suppressive or oncogenic depending on the context(2,3). During lung development, Notch pathway activation inhibits the differentiation of precursor cells to a neuroendocrine (NE) fate(4–6). In small cell lung cancer (SCLC), a...

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Detalles Bibliográficos
Autores principales: Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776014/
https://www.ncbi.nlm.nih.gov/pubmed/28489825
http://dx.doi.org/10.1038/nature22323

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