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Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury
Pumpless extracorporeal lung assist (pECLA) has been reported to efficiently remove the systemic CO(2) production and provide mild to moderate oxygenation, thereby allowing for ventilator settings and modes prioritizing oxygenation and lung protection. However, an adequate bypass flow, the capacity...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776660/ https://www.ncbi.nlm.nih.gov/pubmed/29434789 http://dx.doi.org/10.3892/etm.2017.5656 |
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author | Ju, Zhihai Ma, Jinhui Wang, Chen Yu, Jie Qiao, Yeru Hei, Feilong |
author_facet | Ju, Zhihai Ma, Jinhui Wang, Chen Yu, Jie Qiao, Yeru Hei, Feilong |
author_sort | Ju, Zhihai |
collection | PubMed |
description | Pumpless extracorporeal lung assist (pECLA) has been reported to efficiently remove the systemic CO(2) production and provide mild to moderate oxygenation, thereby allowing for ventilator settings and modes prioritizing oxygenation and lung protection. However, an adequate bypass flow, the capacity to provide respiratory support and the effect on the inflammatory cascade response and tissue perfusion require further study to be determined. After induction of acute lung injury (ALI) by oleic acid injection, pECLA was implemented in 12 anaesthetized and mechanically ventilated dogs for 48 h. Improved oxygenation [partial oxygen pressure (PaO(2)) and oxygen saturation (SaO(2)) was measured by arterial blood gas analysis, and increased by 29 and 18%, respectively] and CO(2) elimination (partial CO(2) pressure decreased by 43.35%) were obtained after pECLA implementation. A maximum arterio-venous shunt flow of up to 25% of the foundational CO resulted in stable hemodynamics. The pECLA procedure did not elicit any further increase in the concentration of tumor necrosis factor-α, interleukin (IL)-6, IL-8 and endothelin-1 compared with that in the group subjected to oleic acid injection only. In addition, the pECLA procedure had no effect on lactate levels and urine production. In conclusion, pECLA is an efficient and promising strategy for providing a mild to moderate oxygenation and adequate decarboxylation, while avoiding excessive inflammatory cascade response and tissue hypoperfusion in an experimental ALI model. |
format | Online Article Text |
id | pubmed-5776660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-57766602018-02-12 Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury Ju, Zhihai Ma, Jinhui Wang, Chen Yu, Jie Qiao, Yeru Hei, Feilong Exp Ther Med Articles Pumpless extracorporeal lung assist (pECLA) has been reported to efficiently remove the systemic CO(2) production and provide mild to moderate oxygenation, thereby allowing for ventilator settings and modes prioritizing oxygenation and lung protection. However, an adequate bypass flow, the capacity to provide respiratory support and the effect on the inflammatory cascade response and tissue perfusion require further study to be determined. After induction of acute lung injury (ALI) by oleic acid injection, pECLA was implemented in 12 anaesthetized and mechanically ventilated dogs for 48 h. Improved oxygenation [partial oxygen pressure (PaO(2)) and oxygen saturation (SaO(2)) was measured by arterial blood gas analysis, and increased by 29 and 18%, respectively] and CO(2) elimination (partial CO(2) pressure decreased by 43.35%) were obtained after pECLA implementation. A maximum arterio-venous shunt flow of up to 25% of the foundational CO resulted in stable hemodynamics. The pECLA procedure did not elicit any further increase in the concentration of tumor necrosis factor-α, interleukin (IL)-6, IL-8 and endothelin-1 compared with that in the group subjected to oleic acid injection only. In addition, the pECLA procedure had no effect on lactate levels and urine production. In conclusion, pECLA is an efficient and promising strategy for providing a mild to moderate oxygenation and adequate decarboxylation, while avoiding excessive inflammatory cascade response and tissue hypoperfusion in an experimental ALI model. D.A. Spandidos 2018-02 2017-12-18 /pmc/articles/PMC5776660/ /pubmed/29434789 http://dx.doi.org/10.3892/etm.2017.5656 Text en Copyright: © Ju et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Ju, Zhihai Ma, Jinhui Wang, Chen Yu, Jie Qiao, Yeru Hei, Feilong Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title | Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title_full | Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title_fullStr | Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title_full_unstemmed | Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title_short | Effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
title_sort | effects of pumpless extracorporeal lung assist on hemodynamics, gas exchange and inflammatory cascade response during experimental lung injury |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776660/ https://www.ncbi.nlm.nih.gov/pubmed/29434789 http://dx.doi.org/10.3892/etm.2017.5656 |
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