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The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776765/ https://www.ncbi.nlm.nih.gov/pubmed/29357818 http://dx.doi.org/10.1186/s12881-017-0518-0 |
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author | Wang, Yu-Jia Chen, Kai-Yun Kuo, Li-Na Wang, Wen-Chang Hsu, Yu-Wen Wong, Henry Sung-Ching Lin, Chien-Min Liao, Kuo-Hsing Zhang, Yan-Feng Chiang, Yung-Hsiao Chang, Wei-Chiao |
author_facet | Wang, Yu-Jia Chen, Kai-Yun Kuo, Li-Na Wang, Wen-Chang Hsu, Yu-Wen Wong, Henry Sung-Ching Lin, Chien-Min Liao, Kuo-Hsing Zhang, Yan-Feng Chiang, Yung-Hsiao Chang, Wei-Chiao |
author_sort | Wang, Yu-Jia |
collection | PubMed |
description | BACKGROUND: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). METHODS: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. RESULTS: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. CONCLUSIONS: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0518-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5776765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57767652018-01-31 The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury Wang, Yu-Jia Chen, Kai-Yun Kuo, Li-Na Wang, Wen-Chang Hsu, Yu-Wen Wong, Henry Sung-Ching Lin, Chien-Min Liao, Kuo-Hsing Zhang, Yan-Feng Chiang, Yung-Hsiao Chang, Wei-Chiao BMC Med Genet Research Article BACKGROUND: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). METHODS: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. RESULTS: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. CONCLUSIONS: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0518-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-01-22 /pmc/articles/PMC5776765/ /pubmed/29357818 http://dx.doi.org/10.1186/s12881-017-0518-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wang, Yu-Jia Chen, Kai-Yun Kuo, Li-Na Wang, Wen-Chang Hsu, Yu-Wen Wong, Henry Sung-Ching Lin, Chien-Min Liao, Kuo-Hsing Zhang, Yan-Feng Chiang, Yung-Hsiao Chang, Wei-Chiao The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title | The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title_full | The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title_fullStr | The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title_full_unstemmed | The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title_short | The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury |
title_sort | association between bdnf val66met polymorphism and emotional symptoms after mild traumatic brain injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776765/ https://www.ncbi.nlm.nih.gov/pubmed/29357818 http://dx.doi.org/10.1186/s12881-017-0518-0 |
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