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C-terminal modification of the insulin B:11–23 peptide creates superagonists in mouse and human type 1 diabetes
A polymorphism at β57 in some major histocompatibility complex class II (MHCII) alleles of rodents and humans is associated with a high risk for developing type 1 diabetes (T1D). However, a highly diabetogenic insulin B chain epitope within the B:9–23 peptide is presented poorly by these alleles to...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776820/ https://www.ncbi.nlm.nih.gov/pubmed/29255035 http://dx.doi.org/10.1073/pnas.1716527115 |