Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway

The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited c...

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Autores principales: Xiao, Xu, Ao, Man, Xu, Fan, Li, Xiao, Hu, Jiuli, Wang, Ying, Li, Daixiao, Zhu, Xiaoqin, Xin, Chunlan, Shi, Wenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776934/
https://www.ncbi.nlm.nih.gov/pubmed/29434864
http://dx.doi.org/10.3892/ol.2017.7519
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author Xiao, Xu
Ao, Man
Xu, Fan
Li, Xiao
Hu, Jiuli
Wang, Ying
Li, Daixiao
Zhu, Xiaoqin
Xin, Chunlan
Shi, Wenda
author_facet Xiao, Xu
Ao, Man
Xu, Fan
Li, Xiao
Hu, Jiuli
Wang, Ying
Li, Daixiao
Zhu, Xiaoqin
Xin, Chunlan
Shi, Wenda
author_sort Xiao, Xu
collection PubMed
description The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner in vitro. In addition, matrine suppressed the 4T1-tumor growth, induced apoptosis, inhibited the expression of vascular endothelial growth factor and downregulated the Wnt/β-catenin signaling pathway in vivo. All these findings indicated that matrine may be a novel effective candidate for the treatment of breast cancer.
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spelling pubmed-57769342018-02-12 Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway Xiao, Xu Ao, Man Xu, Fan Li, Xiao Hu, Jiuli Wang, Ying Li, Daixiao Zhu, Xiaoqin Xin, Chunlan Shi, Wenda Oncol Lett Articles The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner in vitro. In addition, matrine suppressed the 4T1-tumor growth, induced apoptosis, inhibited the expression of vascular endothelial growth factor and downregulated the Wnt/β-catenin signaling pathway in vivo. All these findings indicated that matrine may be a novel effective candidate for the treatment of breast cancer. D.A. Spandidos 2018-02 2017-12-05 /pmc/articles/PMC5776934/ /pubmed/29434864 http://dx.doi.org/10.3892/ol.2017.7519 Text en Copyright: © Xiao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xiao, Xu
Ao, Man
Xu, Fan
Li, Xiao
Hu, Jiuli
Wang, Ying
Li, Daixiao
Zhu, Xiaoqin
Xin, Chunlan
Shi, Wenda
Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title_full Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title_fullStr Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title_full_unstemmed Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title_short Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
title_sort effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the wnt/β-catenin pathway
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776934/
https://www.ncbi.nlm.nih.gov/pubmed/29434864
http://dx.doi.org/10.3892/ol.2017.7519
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