Cargando…

PAK5 overexpression is associated with lung metastasis in osteosarcoma

p21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases, which are associated with cytoskeletal organization, cellular morphogenesis, migration and survival. PAKs are overactive in a number of tumor tissues and have attracted attention as a potential target for cancer therapy. In t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Kun, Zhou, Yan, Tseng, Kuo-Fu, Hu, Haiyan, Li, Kunpeng, Wang, Yaling, Gan, Zhihua, Lin, Shuchen, Sun, Yongning, Min, Daliu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777019/ https://www.ncbi.nlm.nih.gov/pubmed/29434926 http://dx.doi.org/10.3892/ol.2017.7545

Ejemplares similares

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro
por: Gan, Zhihua, et al.
Publicado: (2017)

Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein
por: Wu, Dapeng, et al.
Publicado: (2017)

Long Non-coding RNA MRUL Contributes to Osteosarcoma Progression Through the miR-125a-5p/FUT4 Axis
por: Tian, Cong, et al.
Publicado: (2020)

Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice
por: Furnari, Melody A., et al.
Publicado: (2013)

Monitoring cancer stem cells: insights into clinical oncology
por: Lin, ShuChen, et al.
Publicado: (2016)

PAK5‐stabilized Smuc confers renal cell carcinoma metastasis
por: Huo, Fu‐Chun, et al.
Publicado: (2021)

Mislocalized cytoplasmic p27 activates PAK1‐mediated metastasis and is a prognostic factor in osteosarcoma
por: Chen, Xiang, et al.
Publicado: (2020)

Correlation between chemotherapy resistance in osteosarcoma patients and PAK5 and Ezrin gene expression
por: Liu, Qian, et al.
Publicado: (2018)

Interfering with pak4 Protein Expression Affects Osteosarcoma Cell Proliferation and Migration
por: Fu, Yuxin, et al.
Publicado: (2021)

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
por: Murugesan, Gavuthami, et al.
Publicado: (2022)

Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells
por: Song, Peilu, et al.
Publicado: (2022)

Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells
por: Zhou, Yan, et al.
Publicado: (2016)

Identification of the methotrexate resistance-related diagnostic markers in osteosarcoma via adaptive total variation netNMF and multi-omics datasets
por: Jiang, Zhihan, et al.
Publicado: (2023)

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
por: Eswaran, Jeyanthy, et al.
Publicado: (2007)

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo
por: Li, Ying, et al.
Publicado: (2020)

The Plasma Concentration of D-Dimer is Associated with Neoadjuvant-Chemotherapy Efficacy and the Prognosis in Osteosarcoma
por: Huang, Yujing, et al.
Publicado: (2021)

Establishment of a serological molecular model for the early diagnosis and progression monitoring of bone metastasis in lung cancer
por: Teng, Xiaoyan, et al.
Publicado: (2020)

Overexpression of Notch3 is associated with metastasis and poor prognosis in osteosarcoma patients
por: Tang, Xue-Feng, et al.
Publicado: (2019)

Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature
por: Han, Kun, et al.
Publicado: (2013)

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer
por: Kamai, Takao, et al.
Publicado: (2010)

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions
por: Grebeňová, Dana, et al.
Publicado: (2019)

PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry
por: Li, Chien-Feng, et al.
Publicado: (2023)

Overexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer
por: Yang, Zhiying, et al.
Publicado: (2017)

PAK3 promotes the metastasis of hepatocellular carcinoma by regulating EMT process
por: Gao, Zhi, et al.
Publicado: (2022)

Patrolling monocytes inhibit osteosarcoma metastasis to the lung
por: Chen, Ting, et al.
Publicado: (2020)

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
por: Tan, Xiaohong, et al.
Publicado: (2021)

Osteosarcoma and Metastasis
por: Sheng, Gaohong, et al.
Publicado: (2021)

Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer
por: Khare, Vineeta, et al.
Publicado: (2015)

Overexpression of a Pak Choi Gene, BcAS2, Causes Leaf Curvature in Arabidopsis thaliana
por: Lin, Ye, et al.
Publicado: (2021)

PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells
por: Huang, Silin, et al.
Publicado: (2020)

PAK Signaling in Oncogenesis
por: Molli, Poonam R., et al.
Publicado: (2009)

PAK signaling in cancer
por: Ye, Diana Zi, et al.
Publicado: (2012)

YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma
por: Nigris, Filomena de, et al.
Publicado: (2011)

Overexpression of cytoplasmic β-catenin inhibits the metastasis of the murine osteosarcoma cell line LM8
por: Kidani, Teruki, et al.
Publicado: (2014)

B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis
por: Wang, Ling, et al.
Publicado: (2013)

Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma
por: Wang, Bo, et al.
Publicado: (2015)

Lung Immune Prognostic Index Could Predict Metastasis in Patients With Osteosarcoma
por: He, Xuanhong, et al.
Publicado: (2022)

Expansion of BCR/ABL1 (+) cells requires PAK2 but not PAK1
por: Edlinger, Leo, et al.
Publicado: (2017)

PAK4 signaling in health and disease: defining the PAK4–CREB axis
por: Won, So-Yoon, et al.
Publicado: (2019)

PAK1 and PAK4 as therapeutic targets for Ewing sarcoma: a commentary
por: Parks, Sydney E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ecdbrcmg2hciso7fdldnlv4ee0