Variable outcome and methylation status according to CEBPA mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment

Although CEBPA double-mutated (CEBPA(DM)) acute myeloid leukemia is considered to be a favorable-risk disease, relapse remains a major cause of treatment failure. Most CEBPA(DM) patients have a classic biallelic mutant combination with an N-terminal mutation leading to production of p30 protein plus...

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Detalles Bibliográficos
Autores principales: El-Sharkawi, Dima, Sproul, Duncan, Allen, Christopher G., Feber, Andrew, Wright, Melissa, Hills, Robert K., Linch, David C., Gale, Rosemary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777194/
https://www.ncbi.nlm.nih.gov/pubmed/29025912
http://dx.doi.org/10.3324/haematol.2017.173096

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