Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging

The atypical chemokine receptor ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and CXCL12 to shape and terminate chemotactic gradients during development and immune responses. Although unable to trigger G protein activation, both ligands activate G pro...

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Detalles Bibliográficos
Autores principales: Montpas, Nicolas, St-Onge, Geneviève, Nama, Nassr, Rhainds, David, Benredjem, Besma, Girard, Mélanie, Hickson, Gilles, Pons, Véronique, Heveker, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777261/
https://www.ncbi.nlm.nih.gov/pubmed/29180449
http://dx.doi.org/10.1074/jbc.M117.814947

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