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Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease
COPD is a significant cause of morbidity and mortality. In some patients with COPD, eosinophils contribute to inflammation that promotes airway obstruction; approximately a third of stable COPD patients have evidence of eosinophilic inflammation. Although the eosinophil threshold associated with cli...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777380/ https://www.ncbi.nlm.nih.gov/pubmed/29403271 http://dx.doi.org/10.2147/COPD.S152291 |
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author | Tashkin, Donald P Wechsler, Michael E |
author_facet | Tashkin, Donald P Wechsler, Michael E |
author_sort | Tashkin, Donald P |
collection | PubMed |
description | COPD is a significant cause of morbidity and mortality. In some patients with COPD, eosinophils contribute to inflammation that promotes airway obstruction; approximately a third of stable COPD patients have evidence of eosinophilic inflammation. Although the eosinophil threshold associated with clinical relevance in patients with COPD is currently subject to debate, eosinophil counts hold potential as biomarkers to guide therapy. In particular, eosinophil counts may be useful in assessing which patients may benefit from inhaled corticosteroid therapy, particularly regarding exacerbation prevention. In addition, several therapies targeting eosinophilic inflammation are available or in development, including monoclonal antibodies targeting the IL5 ligand, the IL5 receptor, IL4, and IL13. The goal of this review was to describe the biologic characteristics of eosinophils, their role in COPD during exacerbations and stable disease, and their use as biomarkers to aid treatment decisions. We also propose an algorithm for inhaled corticosteroid use, taking into consideration eosinophil counts and pneumonia history, and emerging eosinophil-targeted therapies in COPD. |
format | Online Article Text |
id | pubmed-5777380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57773802018-02-05 Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease Tashkin, Donald P Wechsler, Michael E Int J Chron Obstruct Pulmon Dis Review COPD is a significant cause of morbidity and mortality. In some patients with COPD, eosinophils contribute to inflammation that promotes airway obstruction; approximately a third of stable COPD patients have evidence of eosinophilic inflammation. Although the eosinophil threshold associated with clinical relevance in patients with COPD is currently subject to debate, eosinophil counts hold potential as biomarkers to guide therapy. In particular, eosinophil counts may be useful in assessing which patients may benefit from inhaled corticosteroid therapy, particularly regarding exacerbation prevention. In addition, several therapies targeting eosinophilic inflammation are available or in development, including monoclonal antibodies targeting the IL5 ligand, the IL5 receptor, IL4, and IL13. The goal of this review was to describe the biologic characteristics of eosinophils, their role in COPD during exacerbations and stable disease, and their use as biomarkers to aid treatment decisions. We also propose an algorithm for inhaled corticosteroid use, taking into consideration eosinophil counts and pneumonia history, and emerging eosinophil-targeted therapies in COPD. Dove Medical Press 2018-01-17 /pmc/articles/PMC5777380/ /pubmed/29403271 http://dx.doi.org/10.2147/COPD.S152291 Text en © 2018 Tashkin and Wechsler. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Tashkin, Donald P Wechsler, Michael E Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title | Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title_full | Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title_fullStr | Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title_full_unstemmed | Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title_short | Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
title_sort | role of eosinophils in airway inflammation of chronic obstructive pulmonary disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777380/ https://www.ncbi.nlm.nih.gov/pubmed/29403271 http://dx.doi.org/10.2147/COPD.S152291 |
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