Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?

Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in th...

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Detalles Bibliográficos
Autores principales: Abassi, Mahsa, Rhein, Joshua, Meya, David B, Boulware, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777480/
https://www.ncbi.nlm.nih.gov/pubmed/29372172
http://dx.doi.org/10.1093/ofid/ofx274
Descripción
Sumario:Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.

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