Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?

Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Abassi, Mahsa, Rhein, Joshua, Meya, David B, Boulware, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777480/
https://www.ncbi.nlm.nih.gov/pubmed/29372172
http://dx.doi.org/10.1093/ofid/ofx274
_version_ 1783294203887878144
author Abassi, Mahsa
Rhein, Joshua
Meya, David B
Boulware, David R
author_facet Abassi, Mahsa
Rhein, Joshua
Meya, David B
Boulware, David R
author_sort Abassi, Mahsa
collection PubMed
description Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.
format Online
Article
Text
id pubmed-5777480
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-57774802018-01-25 Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern? Abassi, Mahsa Rhein, Joshua Meya, David B Boulware, David R Open Forum Infect Dis Brief Report Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes. Oxford University Press 2017-12-26 /pmc/articles/PMC5777480/ /pubmed/29372172 http://dx.doi.org/10.1093/ofid/ofx274 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Abassi, Mahsa
Rhein, Joshua
Meya, David B
Boulware, David R
Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title_full Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title_fullStr Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title_full_unstemmed Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title_short Cryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
title_sort cryptococcal disease in the era of “test and treat”: is there cause for concern?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777480/
https://www.ncbi.nlm.nih.gov/pubmed/29372172
http://dx.doi.org/10.1093/ofid/ofx274
work_keys_str_mv AT abassimahsa cryptococcaldiseaseintheeraoftestandtreatistherecauseforconcern
AT rheinjoshua cryptococcaldiseaseintheeraoftestandtreatistherecauseforconcern
AT meyadavidb cryptococcaldiseaseintheeraoftestandtreatistherecauseforconcern
AT boulwaredavidr cryptococcaldiseaseintheeraoftestandtreatistherecauseforconcern

Ejemplares similares