Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

Targeting the PI3K pathway has achieved limited success in cancer therapy. One reason for the disappointing activity of drugs that interfere with molecules that are important player in this pathway is the induction of multiple feedback loops that have been only partially understood. To understand th...

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Detalles Bibliográficos
Autores principales: Sathe, Anuja, Chalaud, Géraldine, Oppolzer, Immanuel, Wong, Kit Yeng, von Busch, Margarita, Schmid, Sebastian C., Tong, Zhichao, Retz, Margitta, Gschwend, Juergen E., Schulz, Wolfgang A., Nawroth, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777650/
https://www.ncbi.nlm.nih.gov/pubmed/29357370
http://dx.doi.org/10.1371/journal.pone.0190854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777650/
https://www.ncbi.nlm.nih.gov/pubmed/29357370
http://dx.doi.org/10.1371/journal.pone.0190854

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