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Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy
Targeting the PI3K pathway has achieved limited success in cancer therapy. One reason for the disappointing activity of drugs that interfere with molecules that are important player in this pathway is the induction of multiple feedback loops that have been only partially understood. To understand th...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777650/ https://www.ncbi.nlm.nih.gov/pubmed/29357370 http://dx.doi.org/10.1371/journal.pone.0190854 |