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Simultaneous detection of genetic and copy number alterations in BRCA1/2 genes

Germline mutations in BRCA1 and BRCA2 genes (BRCA1/2) predispose to hereditary breast and ovarian cancer syndrome (HBOC), and their dysregulation increases the risk of cancers. The detection of pathogenic BRCA1/2 variants is essential for the diagnosis and prevention of HBOC, and for offering treatm...

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Detalles Bibliográficos
Autores principales:	Hirotsu, Yosuke, Ooka, Yoshihiko, Sakamoto, Ikuko, Nakagomi, Hiroshi, Omata, Masao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777706/ https://www.ncbi.nlm.nih.gov/pubmed/29383094 http://dx.doi.org/10.18632/oncotarget.22962

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