Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AK...

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Detalles Bibliográficos
Autores principales: Yang, Yanping, Zhao, Jieqiong, Zhang, Juan, Lei, Yonghong, Yuan, Fang, Liu, Lu, Gao, Haibo, Guo, Hua, Niu, Xiaolin, Chen, Ruirui, Fu, Xiaobing, Han, Yan, Han, Hua, Chan, Tung, Zhao, Lianyou, Wang, Haichang, Zheng, Qiangsun, Li, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777776/
https://www.ncbi.nlm.nih.gov/pubmed/29383164
http://dx.doi.org/10.18632/oncotarget.23263
Descripción
Sumario:The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.

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