Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AK...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yanping, Zhao, Jieqiong, Zhang, Juan, Lei, Yonghong, Yuan, Fang, Liu, Lu, Gao, Haibo, Guo, Hua, Niu, Xiaolin, Chen, Ruirui, Fu, Xiaobing, Han, Yan, Han, Hua, Chan, Tung, Zhao, Lianyou, Wang, Haichang, Zheng, Qiangsun, Li, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777776/
https://www.ncbi.nlm.nih.gov/pubmed/29383164
http://dx.doi.org/10.18632/oncotarget.23263
_version_ 1783294245626445824
author Yang, Yanping
Zhao, Jieqiong
Zhang, Juan
Lei, Yonghong
Yuan, Fang
Liu, Lu
Gao, Haibo
Guo, Hua
Niu, Xiaolin
Chen, Ruirui
Fu, Xiaobing
Han, Yan
Han, Hua
Chan, Tung
Zhao, Lianyou
Wang, Haichang
Zheng, Qiangsun
Li, Xue
author_facet Yang, Yanping
Zhao, Jieqiong
Zhang, Juan
Lei, Yonghong
Yuan, Fang
Liu, Lu
Gao, Haibo
Guo, Hua
Niu, Xiaolin
Chen, Ruirui
Fu, Xiaobing
Han, Yan
Han, Hua
Chan, Tung
Zhao, Lianyou
Wang, Haichang
Zheng, Qiangsun
Li, Xue
author_sort Yang, Yanping
collection PubMed
description The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.
format Online
Article
Text
id pubmed-5777776
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-57777762018-01-30 Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway Yang, Yanping Zhao, Jieqiong Zhang, Juan Lei, Yonghong Yuan, Fang Liu, Lu Gao, Haibo Guo, Hua Niu, Xiaolin Chen, Ruirui Fu, Xiaobing Han, Yan Han, Hua Chan, Tung Zhao, Lianyou Wang, Haichang Zheng, Qiangsun Li, Xue Oncotarget Research Paper The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction. Impact Journals LLC 2017-12-15 /pmc/articles/PMC5777776/ /pubmed/29383164 http://dx.doi.org/10.18632/oncotarget.23263 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yang, Yanping
Zhao, Jieqiong
Zhang, Juan
Lei, Yonghong
Yuan, Fang
Liu, Lu
Gao, Haibo
Guo, Hua
Niu, Xiaolin
Chen, Ruirui
Fu, Xiaobing
Han, Yan
Han, Hua
Chan, Tung
Zhao, Lianyou
Wang, Haichang
Zheng, Qiangsun
Li, Xue
Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title_full Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title_fullStr Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title_full_unstemmed Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title_short Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
title_sort regulation of macrophage migration in ischemic mouse hearts via an akt2/nba1/spk1 pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777776/
https://www.ncbi.nlm.nih.gov/pubmed/29383164
http://dx.doi.org/10.18632/oncotarget.23263
work_keys_str_mv AT yangyanping regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT zhaojieqiong regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT zhangjuan regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT leiyonghong regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT yuanfang regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT liulu regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT gaohaibo regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT guohua regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT niuxiaolin regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT chenruirui regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT fuxiaobing regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT hanyan regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT hanhua regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT chantung regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT zhaolianyou regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT wanghaichang regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT zhengqiangsun regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway
AT lixue regulationofmacrophagemigrationinischemicmouseheartsviaanakt2nba1spk1pathway

Ejemplares similares