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Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study

PURPOSE: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. MATERIALS AND METHODS: (1)H MR spectroscopy...

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Autores principales: Yeh, Chih-Hua, Lin, Gigin, Wang, Jiun-Jie, Lin, Chien-Yu, Tsai, Shang-Yueh, Lin, Yu-Chun, Wu, Yi-Ming, Ko, Sheung-Fat, Wang, Hung-Ming, Chan, Sheng-Chieh, Yen, Tzu-Chen, Liao, Chun-Ta, Ng, Shu-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777790/
https://www.ncbi.nlm.nih.gov/pubmed/29383178
http://dx.doi.org/10.18632/oncotarget.23306
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author Yeh, Chih-Hua
Lin, Gigin
Wang, Jiun-Jie
Lin, Chien-Yu
Tsai, Shang-Yueh
Lin, Yu-Chun
Wu, Yi-Ming
Ko, Sheung-Fat
Wang, Hung-Ming
Chan, Sheng-Chieh
Yen, Tzu-Chen
Liao, Chun-Ta
Ng, Shu-Hang
author_facet Yeh, Chih-Hua
Lin, Gigin
Wang, Jiun-Jie
Lin, Chien-Yu
Tsai, Shang-Yueh
Lin, Yu-Chun
Wu, Yi-Ming
Ko, Sheung-Fat
Wang, Hung-Ming
Chan, Sheng-Chieh
Yen, Tzu-Chen
Liao, Chun-Ta
Ng, Shu-Hang
author_sort Yeh, Chih-Hua
collection PubMed
description PURPOSE: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. MATERIALS AND METHODS: (1)H MR spectroscopy was performed in addition to conventional MR imaging before definitive chemoradiotherapy in 58 patients with advanced OHSCC. The relationship of local control with the (1)H MR spectroscopy and (18)F-FDG PET/CT parameters was analyzed. RESULTS: With a median follow-up of 17.6 months, 13 (22.4%) patients exhibited local failure; whereas the remaining 45 achieved local control. Kaplan-Meier analysis identified age > 60 years, creatine level on MRS ≦ 6.02 mM, glutamine and glutamate (Glx) level on MRS > 3.31 mM, and total lesion glycolysis (TLG) on (18)F-FDG PET/CT > 217.18 g/mL × mL as significant adverse predictors for 2-year local control. Multivariate Cox regression analysis showed that age (p=0.017), Glx level on MRS (p=0.021), and TLG on (18)F-FDG PET/CT (p=0.028) retained their independent prognostic significance. A scoring system was constructed based on the sum of these three factors. We found that patients with scores of 2–3 had significantly poorer local control rates than patients with scores of 0–1 (33.3% versus 86.8%, p=0.003). CONCLUSION: We conclude that Glx on (1)H MR spectroscopy at 3 T was the independent prognostic factor for local control of OHSCC patients treated with chemoradiotherapy, and its combination with age and TLG may help identify a subgroup of patients at high risk for developing local failure.
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spelling pubmed-57777902018-01-30 Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study Yeh, Chih-Hua Lin, Gigin Wang, Jiun-Jie Lin, Chien-Yu Tsai, Shang-Yueh Lin, Yu-Chun Wu, Yi-Ming Ko, Sheung-Fat Wang, Hung-Ming Chan, Sheng-Chieh Yen, Tzu-Chen Liao, Chun-Ta Ng, Shu-Hang Oncotarget Research Paper PURPOSE: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. MATERIALS AND METHODS: (1)H MR spectroscopy was performed in addition to conventional MR imaging before definitive chemoradiotherapy in 58 patients with advanced OHSCC. The relationship of local control with the (1)H MR spectroscopy and (18)F-FDG PET/CT parameters was analyzed. RESULTS: With a median follow-up of 17.6 months, 13 (22.4%) patients exhibited local failure; whereas the remaining 45 achieved local control. Kaplan-Meier analysis identified age > 60 years, creatine level on MRS ≦ 6.02 mM, glutamine and glutamate (Glx) level on MRS > 3.31 mM, and total lesion glycolysis (TLG) on (18)F-FDG PET/CT > 217.18 g/mL × mL as significant adverse predictors for 2-year local control. Multivariate Cox regression analysis showed that age (p=0.017), Glx level on MRS (p=0.021), and TLG on (18)F-FDG PET/CT (p=0.028) retained their independent prognostic significance. A scoring system was constructed based on the sum of these three factors. We found that patients with scores of 2–3 had significantly poorer local control rates than patients with scores of 0–1 (33.3% versus 86.8%, p=0.003). CONCLUSION: We conclude that Glx on (1)H MR spectroscopy at 3 T was the independent prognostic factor for local control of OHSCC patients treated with chemoradiotherapy, and its combination with age and TLG may help identify a subgroup of patients at high risk for developing local failure. Impact Journals LLC 2017-12-14 /pmc/articles/PMC5777790/ /pubmed/29383178 http://dx.doi.org/10.18632/oncotarget.23306 Text en Copyright: © 2017 Yeh et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yeh, Chih-Hua
Lin, Gigin
Wang, Jiun-Jie
Lin, Chien-Yu
Tsai, Shang-Yueh
Lin, Yu-Chun
Wu, Yi-Ming
Ko, Sheung-Fat
Wang, Hung-Ming
Chan, Sheng-Chieh
Yen, Tzu-Chen
Liao, Chun-Ta
Ng, Shu-Hang
Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title_full Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title_fullStr Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title_full_unstemmed Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title_short Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
title_sort predictive value of 1h mr spectroscopy and 18f-fdg pet/ct for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777790/
https://www.ncbi.nlm.nih.gov/pubmed/29383178
http://dx.doi.org/10.18632/oncotarget.23306
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