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The nasal microbiome mirrors and potentially shapes olfactory function
Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, ide...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778015/ https://www.ncbi.nlm.nih.gov/pubmed/29358754 http://dx.doi.org/10.1038/s41598-018-19438-3 |
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author | Koskinen, Kaisa Reichert, Johanna L. Hoier, Stefan Schachenreiter, Jochen Duller, Stefanie Moissl-Eichinger, Christine Schöpf, Veronika |
author_facet | Koskinen, Kaisa Reichert, Johanna L. Hoier, Stefan Schachenreiter, Jochen Duller, Stefanie Moissl-Eichinger, Christine Schöpf, Veronika |
author_sort | Koskinen, Kaisa |
collection | PubMed |
description | Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell (“good normosmics”) and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds. |
format | Online Article Text |
id | pubmed-5778015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57780152018-01-31 The nasal microbiome mirrors and potentially shapes olfactory function Koskinen, Kaisa Reichert, Johanna L. Hoier, Stefan Schachenreiter, Jochen Duller, Stefanie Moissl-Eichinger, Christine Schöpf, Veronika Sci Rep Article Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell (“good normosmics”) and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds. Nature Publishing Group UK 2018-01-22 /pmc/articles/PMC5778015/ /pubmed/29358754 http://dx.doi.org/10.1038/s41598-018-19438-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Koskinen, Kaisa Reichert, Johanna L. Hoier, Stefan Schachenreiter, Jochen Duller, Stefanie Moissl-Eichinger, Christine Schöpf, Veronika The nasal microbiome mirrors and potentially shapes olfactory function |
title | The nasal microbiome mirrors and potentially shapes olfactory function |
title_full | The nasal microbiome mirrors and potentially shapes olfactory function |
title_fullStr | The nasal microbiome mirrors and potentially shapes olfactory function |
title_full_unstemmed | The nasal microbiome mirrors and potentially shapes olfactory function |
title_short | The nasal microbiome mirrors and potentially shapes olfactory function |
title_sort | nasal microbiome mirrors and potentially shapes olfactory function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778015/ https://www.ncbi.nlm.nih.gov/pubmed/29358754 http://dx.doi.org/10.1038/s41598-018-19438-3 |
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