Gene annotation bias impedes biomedical research

We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypothe...

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Detalles Bibliográficos
Autores principales: Haynes, Winston A., Tomczak, Aurelie, Khatri, Purvesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778030/
https://www.ncbi.nlm.nih.gov/pubmed/29358745
http://dx.doi.org/10.1038/s41598-018-19333-x
Descripción
Sumario:We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses.

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