Gene annotation bias impedes biomedical research

We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypothe...

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Autores principales: Haynes, Winston A., Tomczak, Aurelie, Khatri, Purvesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778030/
https://www.ncbi.nlm.nih.gov/pubmed/29358745
http://dx.doi.org/10.1038/s41598-018-19333-x
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author Haynes, Winston A.
Tomczak, Aurelie
Khatri, Purvesh
author_facet Haynes, Winston A.
Tomczak, Aurelie
Khatri, Purvesh
author_sort Haynes, Winston A.
collection PubMed
description We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses.
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spelling pubmed-57780302018-01-31 Gene annotation bias impedes biomedical research Haynes, Winston A. Tomczak, Aurelie Khatri, Purvesh Sci Rep Article We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses. Nature Publishing Group UK 2018-01-22 /pmc/articles/PMC5778030/ /pubmed/29358745 http://dx.doi.org/10.1038/s41598-018-19333-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Haynes, Winston A.
Tomczak, Aurelie
Khatri, Purvesh
Gene annotation bias impedes biomedical research
title Gene annotation bias impedes biomedical research
title_full Gene annotation bias impedes biomedical research
title_fullStr Gene annotation bias impedes biomedical research
title_full_unstemmed Gene annotation bias impedes biomedical research
title_short Gene annotation bias impedes biomedical research
title_sort gene annotation bias impedes biomedical research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778030/
https://www.ncbi.nlm.nih.gov/pubmed/29358745
http://dx.doi.org/10.1038/s41598-018-19333-x
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