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Physical basis of specificity and delayed binding of a subtype selective sodium channel inhibitor
Nerve and muscle signalling is controlled by voltage-gated sodium (Nav) channels which are the targets of local anesthetics, anti-epileptics and anti-arrythmics. Current medications do not selectively target specific types of Nav found in the body, but compounds that do so have the potential to be b...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778059/ https://www.ncbi.nlm.nih.gov/pubmed/29358762 http://dx.doi.org/10.1038/s41598-018-19850-9 |