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Aminode: Identification of Evolutionary Constraints in the Human Proteome

Evolutionarily constrained regions (ECRs) are a hallmark for sites of critical importance for a protein’s structure or function. ECRs can be inferred by comparing the amino acid sequences from multiple protein homologs in the context of the evolutionary relationships that link the analyzed proteins....

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Detalles Bibliográficos
Autores principales: Chang, Kevin T., Guo, Junyan, di Ronza, Alberto, Sardiello, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778061/
https://www.ncbi.nlm.nih.gov/pubmed/29358731
http://dx.doi.org/10.1038/s41598-018-19744-w