Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

Tianeptine is an atypical antidepressant with a unique mechanism of action and recently it has been also reported that its major metabolite, compound MC5, possesses pharmacological activity similar to that of the parent drug. The current study aims to investigate the pharmacokinetics (PK) of both ti...

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Detalles Bibliográficos
Autores principales: Szafarz, Małgorzata, Wencel, Agnieszka, Pociecha, Krzysztof, Fedak, Filip A., Wlaź, Piotr, Wyska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778159/
https://www.ncbi.nlm.nih.gov/pubmed/29230490
http://dx.doi.org/10.1007/s00210-017-1448-2

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