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Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases

PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). M...

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Autores principales: Luo, Lingyu, Zen, Hao, Xu, Hongrong, Zhu, Yin, Liu, Pi, Xia, Liang, He, Wenhua, Lv, Nonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778161/
https://www.ncbi.nlm.nih.gov/pubmed/29164335
http://dx.doi.org/10.1007/s00404-017-4558-7
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author Luo, Lingyu
Zen, Hao
Xu, Hongrong
Zhu, Yin
Liu, Pi
Xia, Liang
He, Wenhua
Lv, Nonghua
author_facet Luo, Lingyu
Zen, Hao
Xu, Hongrong
Zhu, Yin
Liu, Pi
Xia, Liang
He, Wenhua
Lv, Nonghua
author_sort Luo, Lingyu
collection PubMed
description PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). METHODS: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. APIP diagnosis were based on 2012 Atlanta Criteria. The correlation between APIP types, severity, biochemical parameters and mortality was analyzed. RESULTS: The most common symptoms for APIP were abdominal pain (86.8%) and vomiting (73.6%). The most common causes for APIP were gallstone (36.4%) and hypertriglyceridemia (32.2%) and hypertriglyceridemic APIP was correlated with a higher rate for local complication (P = 0.012). Serum calcium level was negatively correlated with the severity of APIP (P < 0.01). The overall maternal and fetal mortality rate were 3.3% (4/121) and 11.6% (14/121), respectively. The severity of APIP was significantly correlated with higher risks for maternal and fetal death (P < 0.01). 72.7% of moderate-to-severe APIP patients underwent Cesarean section to terminate gestation safely. CONCLUSION: The most common causes of APIP were gallstone and hypertriglyceridemia. Lower level of serum calcium could be used as an indicator for the severity of the APIP. The severity of APIP was associated with higher risk for neonate asphyxia, and maternal and fetal death.
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spelling pubmed-57781612018-02-01 Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases Luo, Lingyu Zen, Hao Xu, Hongrong Zhu, Yin Liu, Pi Xia, Liang He, Wenhua Lv, Nonghua Arch Gynecol Obstet Maternal-Fetal Medicine PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). METHODS: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. APIP diagnosis were based on 2012 Atlanta Criteria. The correlation between APIP types, severity, biochemical parameters and mortality was analyzed. RESULTS: The most common symptoms for APIP were abdominal pain (86.8%) and vomiting (73.6%). The most common causes for APIP were gallstone (36.4%) and hypertriglyceridemia (32.2%) and hypertriglyceridemic APIP was correlated with a higher rate for local complication (P = 0.012). Serum calcium level was negatively correlated with the severity of APIP (P < 0.01). The overall maternal and fetal mortality rate were 3.3% (4/121) and 11.6% (14/121), respectively. The severity of APIP was significantly correlated with higher risks for maternal and fetal death (P < 0.01). 72.7% of moderate-to-severe APIP patients underwent Cesarean section to terminate gestation safely. CONCLUSION: The most common causes of APIP were gallstone and hypertriglyceridemia. Lower level of serum calcium could be used as an indicator for the severity of the APIP. The severity of APIP was associated with higher risk for neonate asphyxia, and maternal and fetal death. Springer Berlin Heidelberg 2017-11-21 2018 /pmc/articles/PMC5778161/ /pubmed/29164335 http://dx.doi.org/10.1007/s00404-017-4558-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Maternal-Fetal Medicine
Luo, Lingyu
Zen, Hao
Xu, Hongrong
Zhu, Yin
Liu, Pi
Xia, Liang
He, Wenhua
Lv, Nonghua
Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title_full Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title_fullStr Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title_full_unstemmed Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title_short Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
title_sort clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
topic Maternal-Fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778161/
https://www.ncbi.nlm.nih.gov/pubmed/29164335
http://dx.doi.org/10.1007/s00404-017-4558-7
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