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The Role of Trypsin:Chymotrypsin in Tissue Repair

Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues. The tissue repair process can be broadly divided into f...

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Detalles Bibliográficos
Autores principales: Shah, Dilip, Mital, Kushal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778189/
https://www.ncbi.nlm.nih.gov/pubmed/29209994
http://dx.doi.org/10.1007/s12325-017-0648-y
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author Shah, Dilip
Mital, Kushal
author_facet Shah, Dilip
Mital, Kushal
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description Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues. The tissue repair process can be broadly divided into four continuous and overlapping phases—hemostasis and coagulation, inflammation, proliferation, and remodeling. If the process is interrupted or halted during any stage, it leads to impaired healing and formation of a chronic wound. Chronic wounds are associated with significant morbidity, mortality, and poor quality of life. Therefore, prompt and effective management of acute tissue injury is necessary to prevent it from progressing to a chronic wound. Proteolytic enzymes have been used to facilitate tissue repair since ancient times. Trypsin:chymotrypsin is an oral proteolytic enzyme preparation which has been in clinical use since the 1960s. It provides better resolution of inflammatory symptoms and promotes speedier recovery of acute tissue injury than several of the other existing enzyme preparations. This review article revisits the role and clinical utility of trypsin:chymotrypsin combination in tissue repair. Funding: Torrent Pharmaceuticals Limited.
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spelling pubmed-57781892018-02-01 The Role of Trypsin:Chymotrypsin in Tissue Repair Shah, Dilip Mital, Kushal Adv Ther Review Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues. The tissue repair process can be broadly divided into four continuous and overlapping phases—hemostasis and coagulation, inflammation, proliferation, and remodeling. If the process is interrupted or halted during any stage, it leads to impaired healing and formation of a chronic wound. Chronic wounds are associated with significant morbidity, mortality, and poor quality of life. Therefore, prompt and effective management of acute tissue injury is necessary to prevent it from progressing to a chronic wound. Proteolytic enzymes have been used to facilitate tissue repair since ancient times. Trypsin:chymotrypsin is an oral proteolytic enzyme preparation which has been in clinical use since the 1960s. It provides better resolution of inflammatory symptoms and promotes speedier recovery of acute tissue injury than several of the other existing enzyme preparations. This review article revisits the role and clinical utility of trypsin:chymotrypsin combination in tissue repair. Funding: Torrent Pharmaceuticals Limited. Springer Healthcare 2017-12-05 2018 /pmc/articles/PMC5778189/ /pubmed/29209994 http://dx.doi.org/10.1007/s12325-017-0648-y Text en © The Author(s) 2017 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Shah, Dilip
Mital, Kushal
The Role of Trypsin:Chymotrypsin in Tissue Repair
title The Role of Trypsin:Chymotrypsin in Tissue Repair
title_full The Role of Trypsin:Chymotrypsin in Tissue Repair
title_fullStr The Role of Trypsin:Chymotrypsin in Tissue Repair
title_full_unstemmed The Role of Trypsin:Chymotrypsin in Tissue Repair
title_short The Role of Trypsin:Chymotrypsin in Tissue Repair
title_sort role of trypsin:chymotrypsin in tissue repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778189/
https://www.ncbi.nlm.nih.gov/pubmed/29209994
http://dx.doi.org/10.1007/s12325-017-0648-y
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