Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?

AIM: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. PATIENTS & METHODS: This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 ...

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Autores principales: Fotakopoulos, George, Fountas, Kostas, Tsianaka, Eleni, Kotlia, Polikceni, Pachatouridis, Dimitrios, Paschalis, Thanos, Voulgaris, Spyridon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2017
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778376/
https://www.ncbi.nlm.nih.gov/pubmed/29379636
http://dx.doi.org/10.4155/fsoa-2017-0103
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author Fotakopoulos, George
Fountas, Kostas
Tsianaka, Eleni
Kotlia, Polikceni
Pachatouridis, Dimitrios
Paschalis, Thanos
Voulgaris, Spyridon
author_facet Fotakopoulos, George
Fountas, Kostas
Tsianaka, Eleni
Kotlia, Polikceni
Pachatouridis, Dimitrios
Paschalis, Thanos
Voulgaris, Spyridon
author_sort Fotakopoulos, George
collection PubMed
description AIM: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. PATIENTS & METHODS: This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient. RESULTS: Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001). CONCLUSION: Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS.
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spelling pubmed-57783762018-01-29 Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas? Fotakopoulos, George Fountas, Kostas Tsianaka, Eleni Kotlia, Polikceni Pachatouridis, Dimitrios Paschalis, Thanos Voulgaris, Spyridon Future Sci OA Preliminary Communication AIM: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. PATIENTS & METHODS: This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient. RESULTS: Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001). CONCLUSION: Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS. Future Science Ltd 2017-11-10 /pmc/articles/PMC5778376/ /pubmed/29379636 http://dx.doi.org/10.4155/fsoa-2017-0103 Text en © 2017 George Fotakopoulos This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Preliminary Communication
Fotakopoulos, George
Fountas, Kostas
Tsianaka, Eleni
Kotlia, Polikceni
Pachatouridis, Dimitrios
Paschalis, Thanos
Voulgaris, Spyridon
Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title_full Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title_fullStr Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title_full_unstemmed Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title_short Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
title_sort could igf-i levels play a neuroprotective role in patients with large vestibular schwannomas?
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778376/
https://www.ncbi.nlm.nih.gov/pubmed/29379636
http://dx.doi.org/10.4155/fsoa-2017-0103
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