In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules

AIM: To study the in vitro and in vivo anticandidal activity of nanocapsulated bovine lactoferrin. MATERIALS & METHODS: In vitro and in vivo antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs). RESULTS: The NCs showed good anticandidal activities. T...

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Autores principales: Leng, Khoo Miew, Vijayarathna, Soundararajan, Jothy, Subramanion L, Sasidharan, Sreenivasan, Kanwar, Jagat R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778379/
https://www.ncbi.nlm.nih.gov/pubmed/29379633
http://dx.doi.org/10.4155/fsoa-2017-0085
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author Leng, Khoo Miew
Vijayarathna, Soundararajan
Jothy, Subramanion L
Sasidharan, Sreenivasan
Kanwar, Jagat R
author_facet Leng, Khoo Miew
Vijayarathna, Soundararajan
Jothy, Subramanion L
Sasidharan, Sreenivasan
Kanwar, Jagat R
author_sort Leng, Khoo Miew
collection PubMed
description AIM: To study the in vitro and in vivo anticandidal activity of nanocapsulated bovine lactoferrin. MATERIALS & METHODS: In vitro and in vivo antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs). RESULTS: The NCs showed good anticandidal activities. The disruption of cell wall and cell membrane was noted via microscopy studies. The NCs changed the normal growth profile of Candida albicans. NCs reduced the colony forming unit in kidney and blood samples. Histopathological examination showed better cell structure and coordination compared with untreated mice kidney. NCs also enhanced the natural killing properties of C. albicans by epithelial cells. CONCLUSION: NCs have effective anticandidal properties and have the potential as a therapeutic agent against candidiasis.
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spelling pubmed-57783792018-01-29 In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules Leng, Khoo Miew Vijayarathna, Soundararajan Jothy, Subramanion L Sasidharan, Sreenivasan Kanwar, Jagat R Future Sci OA Research Article AIM: To study the in vitro and in vivo anticandidal activity of nanocapsulated bovine lactoferrin. MATERIALS & METHODS: In vitro and in vivo antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs). RESULTS: The NCs showed good anticandidal activities. The disruption of cell wall and cell membrane was noted via microscopy studies. The NCs changed the normal growth profile of Candida albicans. NCs reduced the colony forming unit in kidney and blood samples. Histopathological examination showed better cell structure and coordination compared with untreated mice kidney. NCs also enhanced the natural killing properties of C. albicans by epithelial cells. CONCLUSION: NCs have effective anticandidal properties and have the potential as a therapeutic agent against candidiasis. Future Science Ltd 2017-11-16 /pmc/articles/PMC5778379/ /pubmed/29379633 http://dx.doi.org/10.4155/fsoa-2017-0085 Text en © 2017 KM Leng, S Vijayarathna, SL Johty, S Sasidharan & JR Kanwar This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Leng, Khoo Miew
Vijayarathna, Soundararajan
Jothy, Subramanion L
Sasidharan, Sreenivasan
Kanwar, Jagat R
In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title_full In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title_fullStr In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title_full_unstemmed In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title_short In vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
title_sort in vitro and in vivo anticandidal activities of alginate-enclosed chitosan–calcium phosphate-loaded fe-bovine lactoferrin nanocapsules
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778379/
https://www.ncbi.nlm.nih.gov/pubmed/29379633
http://dx.doi.org/10.4155/fsoa-2017-0085
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