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Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?

INTRODUCTION: Dyshomeostasis of essential trace elements including iron and copper plays a key role in the pathogenesis of a myriad of serious conditions including iron deficiency (ID) anemia, in which impaired cellular energy metabolism is prominent. Although experimental studies documented decreas...

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Autores principales: Bahadir, Aysenur, Erduran, Erol, Değer, Orhan, Birinci, Yelda, Ayar, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778412/
https://www.ncbi.nlm.nih.gov/pubmed/29379545
http://dx.doi.org/10.5114/aoms.2016.59602
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author Bahadir, Aysenur
Erduran, Erol
Değer, Orhan
Birinci, Yelda
Ayar, Ahmet
author_facet Bahadir, Aysenur
Erduran, Erol
Değer, Orhan
Birinci, Yelda
Ayar, Ahmet
author_sort Bahadir, Aysenur
collection PubMed
description INTRODUCTION: Dyshomeostasis of essential trace elements including iron and copper plays a key role in the pathogenesis of a myriad of serious conditions including iron deficiency (ID) anemia, in which impaired cellular energy metabolism is prominent. Although experimental studies documented decreased activity of cytochrome c oxidase (CytOx) in ID, there are not enough clinical data. The present study was conducted to determine serum copper levels and activity of mitochondrial CytOx in isolated lymphocytes of patients with iron deficiency. MATERIAL AND METHODS: A total of 210 cases (2–17 years) were included in this prospective study. Serum iron and copper levels were measured. According to the serum iron levels, patients were allocated to iron deficient (ID, n = 70) and iron deficiency anemia (IDA, n = 70) groups, and iron-sufficient participants were allocated to the control group (n = 70). Activity of CytOx in the circulating lymphocytes was colorimetrically measured and compared with the controls. RESULTS: The CytOx activity was significantly higher in the IDA (2.9 ±1.2 mOD/min, n = 62) group compared to the control group (2.4 ±1.3 mOD/min, n = 68, p < 0.001). Interestingly, serum copper levels were significantly higher in both the ID (106.9 ±55.5 μg/dl, n = 64, p = 0.0001) and IDA (115.1 ±50.2 μg/dl, n = 59, p = 0.0001) groups than the control group (72.1 ±46.7 μg/dl, n = 69). CONCLUSIONS: Higher serum copper levels in patients with IDA implicate co-operative interaction between these trace elements. The elevated CytOx activity in patients with IDA is probably secondary to the normal/elevated serum copper levels.
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spelling pubmed-57784122018-01-29 Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper? Bahadir, Aysenur Erduran, Erol Değer, Orhan Birinci, Yelda Ayar, Ahmet Arch Med Sci Clinical Research INTRODUCTION: Dyshomeostasis of essential trace elements including iron and copper plays a key role in the pathogenesis of a myriad of serious conditions including iron deficiency (ID) anemia, in which impaired cellular energy metabolism is prominent. Although experimental studies documented decreased activity of cytochrome c oxidase (CytOx) in ID, there are not enough clinical data. The present study was conducted to determine serum copper levels and activity of mitochondrial CytOx in isolated lymphocytes of patients with iron deficiency. MATERIAL AND METHODS: A total of 210 cases (2–17 years) were included in this prospective study. Serum iron and copper levels were measured. According to the serum iron levels, patients were allocated to iron deficient (ID, n = 70) and iron deficiency anemia (IDA, n = 70) groups, and iron-sufficient participants were allocated to the control group (n = 70). Activity of CytOx in the circulating lymphocytes was colorimetrically measured and compared with the controls. RESULTS: The CytOx activity was significantly higher in the IDA (2.9 ±1.2 mOD/min, n = 62) group compared to the control group (2.4 ±1.3 mOD/min, n = 68, p < 0.001). Interestingly, serum copper levels were significantly higher in both the ID (106.9 ±55.5 μg/dl, n = 64, p = 0.0001) and IDA (115.1 ±50.2 μg/dl, n = 59, p = 0.0001) groups than the control group (72.1 ±46.7 μg/dl, n = 69). CONCLUSIONS: Higher serum copper levels in patients with IDA implicate co-operative interaction between these trace elements. The elevated CytOx activity in patients with IDA is probably secondary to the normal/elevated serum copper levels. Termedia Publishing House 2016-04-27 2018-01 /pmc/articles/PMC5778412/ /pubmed/29379545 http://dx.doi.org/10.5114/aoms.2016.59602 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Bahadir, Aysenur
Erduran, Erol
Değer, Orhan
Birinci, Yelda
Ayar, Ahmet
Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title_full Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title_fullStr Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title_full_unstemmed Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title_short Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
title_sort augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778412/
https://www.ncbi.nlm.nih.gov/pubmed/29379545
http://dx.doi.org/10.5114/aoms.2016.59602
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