Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors

Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. Here we describe crystal structures of influenza A and B polymerase bound to a capped primer in a configuration consistent with transcription initiation (’priming state’)...

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Detalles Bibliográficos
Autores principales: Pflug, Alexander, Gaudon, Stephanie, Resa-Infante, Patricia, Lethier, Mathilde, Reich, Stefan, Schulze, Wiebke M, Cusack, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778463/
https://www.ncbi.nlm.nih.gov/pubmed/29202182
http://dx.doi.org/10.1093/nar/gkx1210

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