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Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

Prokaryotes encode various host defense systems that provide protection against mobile genetic elements. Restriction–modification (R–M) and CRISPR–Cas systems mediate host defense by sequence specific targeting of invasive DNA. T-even bacteriophages employ covalent modifications of nucleobases to av...

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Detalles Bibliográficos
Autores principales:	Vlot, Marnix, Houkes, Joep, Lochs, Silke J A, Swarts, Daan C, Zheng, Peiyuan, Kunne, Tim, Mohanraju, Prarthana, Anders, Carolin, Jinek, Martin, van der Oost, John, Dickman, Mark J, Brouns, Stan J J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778469/ https://www.ncbi.nlm.nih.gov/pubmed/29253268 http://dx.doi.org/10.1093/nar/gkx1264

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