Crystal structure of 8-(4-methyl­phen­yl)-2′-de­oxy­adenosine hemihydrate

In the asymmetric unit, equalling the unit cell (triclinic, P1, Z = 1), two mol­ecules of the title compound, 8-(4-methyl­phen­yl)-d-2′-de­oxy­adenosine, C(17)H(19)N(5)O(3), are present, with distinct conformations of the two sugar moieties, together with one solvent water mol­ecule. All three ribose O atoms are involved in hydrogen bonding and the crystal packing is largely determined by hydrogen-bonding or hydrogen–heteroatom inter­actions (O—H⋯O, O—H⋯N, N—H⋯O, C—H⋯O and C—H⋯N) with one independent mol­ecule directly linked to four neighbouring mol­ecules and the other mol­ecule directly linked to six neighbouring mol­ecules. The two independent mol­ecules of the asymmetric unit display three weak intra­molecular C—H-to-heteroatom contacts, two of which are very similar despite the different conformations of the deoxyribosyl moieties. The aromatic ring systems of both mol­ecules are in proximity to each other and somehow aligned, though not coplanar. The absolute structures of the two mol­ecules were assumed with reference to the reactant 8-bromo-d-2′-de­oxy­adenosine as they could not be determined crystallographically.