Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide

The asymmetric unit of the crystal of the title compound (common name rivaroxaban), C(19)H(18)ClN(3)O(5), contains two rivaroxaban mol­ecules with different conformations; the C—C—N—C torsion angles between the oxazolidine and thio­phene rings are −171.1 (7) and −106.8 (9)° in the two independent mo...

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Detalles Bibliográficos
Autores principales: Shen, Jie, Tang, Gu-Ping, Hu, Xiu-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778484/
https://www.ncbi.nlm.nih.gov/pubmed/29416890
http://dx.doi.org/10.1107/S2056989017017819
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author Shen, Jie
Tang, Gu-Ping
Hu, Xiu-Rong
author_facet Shen, Jie
Tang, Gu-Ping
Hu, Xiu-Rong
author_sort Shen, Jie
collection PubMed
description The asymmetric unit of the crystal of the title compound (common name rivaroxaban), C(19)H(18)ClN(3)O(5), contains two rivaroxaban mol­ecules with different conformations; the C—C—N—C torsion angles between the oxazolidine and thio­phene rings are −171.1 (7) and −106.8 (9)° in the two independent mol­ecules. In the crystal, classical N—H⋯O hydrogen bonds and weak C—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional supra­molecular architecture.
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spelling pubmed-57784842018-02-07 Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide Shen, Jie Tang, Gu-Ping Hu, Xiu-Rong Acta Crystallogr E Crystallogr Commun Research Communications The asymmetric unit of the crystal of the title compound (common name rivaroxaban), C(19)H(18)ClN(3)O(5), contains two rivaroxaban mol­ecules with different conformations; the C—C—N—C torsion angles between the oxazolidine and thio­phene rings are −171.1 (7) and −106.8 (9)° in the two independent mol­ecules. In the crystal, classical N—H⋯O hydrogen bonds and weak C—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional supra­molecular architecture. International Union of Crystallography 2018-01-01 /pmc/articles/PMC5778484/ /pubmed/29416890 http://dx.doi.org/10.1107/S2056989017017819 Text en © Shen et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Shen, Jie
Tang, Gu-Ping
Hu, Xiu-Rong
Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title_full Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title_fullStr Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title_full_unstemmed Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title_short Crystal structure of (S)-5-chloro-N-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
title_sort crystal structure of (s)-5-chloro-n-({2-oxo-3-[4-(3-oxomorpholin-4-yl)phen­yl]oxazolidin-5-yl}meth­yl)thio­phene-2-carboxamide
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778484/
https://www.ncbi.nlm.nih.gov/pubmed/29416890
http://dx.doi.org/10.1107/S2056989017017819
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AT huxiurong crystalstructureofs5chloron2oxo343oxomorpholin4ylphenyloxazolidin5ylmethylthiophene2carboxamide

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