The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

The post-translational modification poly(ADP-ribosyl)ation (PARylation) plays key roles in genome maintenance and transcription. Both non-covalent poly(ADP-ribose) binding and covalent PARylation control protein functions, however, it is unknown how the two modes of modification crosstalk mechanisti...

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Detalles Bibliográficos
Autores principales: Fischbach, Arthur, Krüger, Annika, Hampp, Stephanie, Assmann, Greta, Rank, Lisa, Hufnagel, Matthias, Stöckl, Martin T, Fischer, Jan M.F, Veith, Sebastian, Rossatti, Pascal, Ganz, Magdalena, Ferrando-May, Elisa, Hartwig, Andrea, Hauser, Karin, Wiesmüller, Lisa, Bürkle, Alexander, Mangerich, Aswin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778597/
https://www.ncbi.nlm.nih.gov/pubmed/29216372
http://dx.doi.org/10.1093/nar/gkx1205

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