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Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes

The human CST (Ctc1, Stn1 and Ten1) complex binds the telomeric overhang and regulates telomere length by promoting C-strand replication and inhibiting telomerase-dependent G-strand synthesis. Structural and biochemical studies on the human Stn1 and Ten1 complex revealed its mechanism of assembly an...

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Detalles Bibliográficos
Autores principales:	Shastrula, Prashanth K, Rice, Cory T, Wang, Zhuo, Lieberman, Paul M, Skordalakes, Emmanuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778599/ https://www.ncbi.nlm.nih.gov/pubmed/29228254 http://dx.doi.org/10.1093/nar/gkx1213

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