Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Sequences with the potential to form RNA G-quadruplexes (G4s) are common in mammalian introns, especially in the proximity of the 5′ splice site (5′SS). However, the difficulty of demonstrating that G4s form in pre-mRNA in functional conditions has meant that little is known about their effects or m...

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Detalles Bibliográficos
Autores principales: Weldon, Carika, Dacanay, Justine G, Gokhale, Vijay, Boddupally, Peda Venkat L, Behm-Ansmant, Isabelle, Burley, Glenn A, Branlant, Christiane, Hurley, Laurence H, Dominguez, Cyril, Eperon, Ian C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778605/
https://www.ncbi.nlm.nih.gov/pubmed/29156002
http://dx.doi.org/10.1093/nar/gkx1122

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