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Single-molecule compaction of megabase-long chromatin molecules by multivalent cations

To gain insight into the conformational properties and compaction of megabase-long chromatin molecules, we reconstituted chromatin from T4 phage DNA (165 kb) and recombinant human histone octamers (HO). The unimolecular compaction, induced by divalent Mg(2+) or tetravalent spermine(4+) cations, stud...

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Detalles Bibliográficos
Autores principales:	Zinchenko, Anatoly, Berezhnoy, Nikolay V, Wang, Sai, Rosencrans, William M, Korolev, Nikolay, van der Maarel, Johan R C, Nordenskiöld, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778610/ https://www.ncbi.nlm.nih.gov/pubmed/29145649 http://dx.doi.org/10.1093/nar/gkx1135

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