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Hepatitis B infection and preeclampsia among pregnant Sudanese women

BACKGROUND: Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including Sudan. The aim of the present study was to investigate the association between H...

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Autores principales: Ahmed, Mohamed A., Sharif, Manal E., Rayis, Duria A., Nasr, Abubakr M., Adam, Ishag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778691/
https://www.ncbi.nlm.nih.gov/pubmed/29357885
http://dx.doi.org/10.1186/s12985-018-0927-5
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author Ahmed, Mohamed A.
Sharif, Manal E.
Rayis, Duria A.
Nasr, Abubakr M.
Adam, Ishag
author_facet Ahmed, Mohamed A.
Sharif, Manal E.
Rayis, Duria A.
Nasr, Abubakr M.
Adam, Ishag
author_sort Ahmed, Mohamed A.
collection PubMed
description BACKGROUND: Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including Sudan. The aim of the present study was to investigate the association between HBsAg seropositivity and preeclampsia. METHODS: A case –controls study (200 women in each arm) was conducted at Saad Abualila Maternity Hospital, Khartoum, Sudan. The cases were women with preeclampsia and the controls were healthy pregnant women. Socio-demographic characteristics were gathered using questionnaire and HBsAg was investigated using an ELISA. RESULTS: There was no significant difference between the cases and the controls in their age, parity, residence, education and blood groups. The majority of the cases were mild preeclampsia (159; 79.5%). In comparison with the controls, a significantly higher number of the cases were HBsAg seropositive [30 (15.0%) vs.12 (6.0%), P = 0.005]. In binary regression women with HBsAg seropositive were at higher risk of preeclampsia than women who were HBsAg seronegative (OR = 2.86, 95%, CI = 1.41–5.79, P = 0.003). CONCLUSION: In the current study HBsAg seropositivity is associated with preeclampsia. Preventive measure should be implemented.
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spelling pubmed-57786912018-01-31 Hepatitis B infection and preeclampsia among pregnant Sudanese women Ahmed, Mohamed A. Sharif, Manal E. Rayis, Duria A. Nasr, Abubakr M. Adam, Ishag Virol J Research BACKGROUND: Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including Sudan. The aim of the present study was to investigate the association between HBsAg seropositivity and preeclampsia. METHODS: A case –controls study (200 women in each arm) was conducted at Saad Abualila Maternity Hospital, Khartoum, Sudan. The cases were women with preeclampsia and the controls were healthy pregnant women. Socio-demographic characteristics were gathered using questionnaire and HBsAg was investigated using an ELISA. RESULTS: There was no significant difference between the cases and the controls in their age, parity, residence, education and blood groups. The majority of the cases were mild preeclampsia (159; 79.5%). In comparison with the controls, a significantly higher number of the cases were HBsAg seropositive [30 (15.0%) vs.12 (6.0%), P = 0.005]. In binary regression women with HBsAg seropositive were at higher risk of preeclampsia than women who were HBsAg seronegative (OR = 2.86, 95%, CI = 1.41–5.79, P = 0.003). CONCLUSION: In the current study HBsAg seropositivity is associated with preeclampsia. Preventive measure should be implemented. BioMed Central 2018-01-22 /pmc/articles/PMC5778691/ /pubmed/29357885 http://dx.doi.org/10.1186/s12985-018-0927-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ahmed, Mohamed A.
Sharif, Manal E.
Rayis, Duria A.
Nasr, Abubakr M.
Adam, Ishag
Hepatitis B infection and preeclampsia among pregnant Sudanese women
title Hepatitis B infection and preeclampsia among pregnant Sudanese women
title_full Hepatitis B infection and preeclampsia among pregnant Sudanese women
title_fullStr Hepatitis B infection and preeclampsia among pregnant Sudanese women
title_full_unstemmed Hepatitis B infection and preeclampsia among pregnant Sudanese women
title_short Hepatitis B infection and preeclampsia among pregnant Sudanese women
title_sort hepatitis b infection and preeclampsia among pregnant sudanese women
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778691/
https://www.ncbi.nlm.nih.gov/pubmed/29357885
http://dx.doi.org/10.1186/s12985-018-0927-5
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