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Establishment of hematological reference intervals for healthy adults in Asmara

OBJECTIVES: Clinical laboratory reference intervals used in a specific area should be derived from the local population as they are influenced by many factors. The purpose of this quantitative cross sectional study was to establish hematological reference intervals for healthy adults in Asmara and t...

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Autores principales: Siraj, Nejat, Issac, John, Anwar, Mohammed, Mehari, Yohannes, Russom, Shushan, Kahsay, Semere, Frezghi, Haben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778762/
https://www.ncbi.nlm.nih.gov/pubmed/29357920
http://dx.doi.org/10.1186/s13104-018-3142-y
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author Siraj, Nejat
Issac, John
Anwar, Mohammed
Mehari, Yohannes
Russom, Shushan
Kahsay, Semere
Frezghi, Haben
author_facet Siraj, Nejat
Issac, John
Anwar, Mohammed
Mehari, Yohannes
Russom, Shushan
Kahsay, Semere
Frezghi, Haben
author_sort Siraj, Nejat
collection PubMed
description OBJECTIVES: Clinical laboratory reference intervals used in a specific area should be derived from the local population as they are influenced by many factors. The purpose of this quantitative cross sectional study was to establish hematological reference intervals for healthy adults in Asmara and to determine whether the currently used reference interval do represent the adult population in the city. In addition, the established reference intervals were compared to findings from similar studies conducted in selected countries in Africa. RESULTS: There was a significant difference between males and females in the reference intervals for erythrocyte count, hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and differential white blood cell count. All the evaluated hematological analytes were found to be higher in males than in females except for platelet count. The out of range percentage for the parameters extends from 3.5 to 46.7%; with red blood cell count having the lowest while mean cell volume having the highest out of range percentage. The results indicated that the currently used reference interval does not represent the population in Asmara and are different from those obtained elsewhere in Africa. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3142-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-57787622018-01-31 Establishment of hematological reference intervals for healthy adults in Asmara Siraj, Nejat Issac, John Anwar, Mohammed Mehari, Yohannes Russom, Shushan Kahsay, Semere Frezghi, Haben BMC Res Notes Research Note OBJECTIVES: Clinical laboratory reference intervals used in a specific area should be derived from the local population as they are influenced by many factors. The purpose of this quantitative cross sectional study was to establish hematological reference intervals for healthy adults in Asmara and to determine whether the currently used reference interval do represent the adult population in the city. In addition, the established reference intervals were compared to findings from similar studies conducted in selected countries in Africa. RESULTS: There was a significant difference between males and females in the reference intervals for erythrocyte count, hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and differential white blood cell count. All the evaluated hematological analytes were found to be higher in males than in females except for platelet count. The out of range percentage for the parameters extends from 3.5 to 46.7%; with red blood cell count having the lowest while mean cell volume having the highest out of range percentage. The results indicated that the currently used reference interval does not represent the population in Asmara and are different from those obtained elsewhere in Africa. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3142-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-01-22 /pmc/articles/PMC5778762/ /pubmed/29357920 http://dx.doi.org/10.1186/s13104-018-3142-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Siraj, Nejat
Issac, John
Anwar, Mohammed
Mehari, Yohannes
Russom, Shushan
Kahsay, Semere
Frezghi, Haben
Establishment of hematological reference intervals for healthy adults in Asmara
title Establishment of hematological reference intervals for healthy adults in Asmara
title_full Establishment of hematological reference intervals for healthy adults in Asmara
title_fullStr Establishment of hematological reference intervals for healthy adults in Asmara
title_full_unstemmed Establishment of hematological reference intervals for healthy adults in Asmara
title_short Establishment of hematological reference intervals for healthy adults in Asmara
title_sort establishment of hematological reference intervals for healthy adults in asmara
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778762/
https://www.ncbi.nlm.nih.gov/pubmed/29357920
http://dx.doi.org/10.1186/s13104-018-3142-y
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