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Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

BACKGROUND: Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centrosome-related events. However, the cellular consequences of such phosphorylatio...

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Detalles Bibliográficos
Autores principales:	Madero-Pérez, Jesús, Fdez, Elena, Fernández, Belén, Lara Ordóñez, Antonio J., Blanca Ramírez, Marian, Gómez-Suaga, Patricia, Waschbüsch, Dieter, Lobbestael, Evy, Baekelandt, Veerle, Nairn, Angus C., Ruiz-Martínez, Javier, Aiastui, Ana, López de Munain, Adolfo, Lis, Pawel, Comptdaer, Thomas, Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine, Beilina, Alexandria, Gonnelli, Adriano, Cookson, Mark R., Greggio, Elisa, Hilfiker, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778812/ https://www.ncbi.nlm.nih.gov/pubmed/29357897 http://dx.doi.org/10.1186/s13024-018-0235-y

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