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Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma

The clinical significance of the sodium-potassium ATPase regulator FXYD domain-containing ion transport regulator 3 (FXYD3) has been demonstrated in a number of types of cancer. However, the role of this protein in human hepatocellular carcinoma (HCC) remains to be elucidated. In the present study,...

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Autores principales: Wang, Li-Juan, Li, Qi-Jiong, Le, Yong, Ouyang, Han-Yue, He, Min-Ke, Yu, Zi-Shan, Zhang, Yong-Fa, Shi, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778849/
https://www.ncbi.nlm.nih.gov/pubmed/29435033
http://dx.doi.org/10.3892/ol.2017.7688
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author Wang, Li-Juan
Li, Qi-Jiong
Le, Yong
Ouyang, Han-Yue
He, Min-Ke
Yu, Zi-Shan
Zhang, Yong-Fa
Shi, Ming
author_facet Wang, Li-Juan
Li, Qi-Jiong
Le, Yong
Ouyang, Han-Yue
He, Min-Ke
Yu, Zi-Shan
Zhang, Yong-Fa
Shi, Ming
author_sort Wang, Li-Juan
collection PubMed
description The clinical significance of the sodium-potassium ATPase regulator FXYD domain-containing ion transport regulator 3 (FXYD3) has been demonstrated in a number of types of cancer. However, the role of this protein in human hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, 217 HCC tissue samples were analyzed to evaluate the expression and prognostic significance of FXYD3 in HCC. Reverse transcription-quantitative polymerase chain reaction was used to analyze the mRNA expression of FXYD3 in 80 primary HCC specimens and paired non-cancerous liver tissue samples, while western blotting was used to analyze the protein expression level of FXYD3 in another 24 pairs. These analyses demonstrated that the expression level of FXYD3 was significantly increasedb at the mRNA and protein levels in HCC tumor tissues compared with adjacent non-cancerous tissues. Immunohistochemical analysis of 137 paraffin-embedded HCC tissue samples indicated that the expression of FXYD3 was associated with HCC clinicopathological characteristics. Kaplan-Meier analysis demonstrated that patients with high FXYD3 protein expression (n=60) experienced significantly poorer overall survival time compared with patients with low FXYD3 protein expression (n=77) (P<0.001). Multivariate analysis demonstrated that FYXD3 protein expression level (hazard ratio, 2.137; 95% confidence interval, 1.224–3.732; P=0.008) was an independent prognostic factor in patients with HCC. Overall, the results indicated that FXYD3 expression levels were higher in HCC tumor tissues than in adjacent non-cancerous tissues, and that the FXYD3 protein may serve as a prognostic marker for HCC.
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spelling pubmed-57788492018-02-12 Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma Wang, Li-Juan Li, Qi-Jiong Le, Yong Ouyang, Han-Yue He, Min-Ke Yu, Zi-Shan Zhang, Yong-Fa Shi, Ming Oncol Lett Articles The clinical significance of the sodium-potassium ATPase regulator FXYD domain-containing ion transport regulator 3 (FXYD3) has been demonstrated in a number of types of cancer. However, the role of this protein in human hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, 217 HCC tissue samples were analyzed to evaluate the expression and prognostic significance of FXYD3 in HCC. Reverse transcription-quantitative polymerase chain reaction was used to analyze the mRNA expression of FXYD3 in 80 primary HCC specimens and paired non-cancerous liver tissue samples, while western blotting was used to analyze the protein expression level of FXYD3 in another 24 pairs. These analyses demonstrated that the expression level of FXYD3 was significantly increasedb at the mRNA and protein levels in HCC tumor tissues compared with adjacent non-cancerous tissues. Immunohistochemical analysis of 137 paraffin-embedded HCC tissue samples indicated that the expression of FXYD3 was associated with HCC clinicopathological characteristics. Kaplan-Meier analysis demonstrated that patients with high FXYD3 protein expression (n=60) experienced significantly poorer overall survival time compared with patients with low FXYD3 protein expression (n=77) (P<0.001). Multivariate analysis demonstrated that FYXD3 protein expression level (hazard ratio, 2.137; 95% confidence interval, 1.224–3.732; P=0.008) was an independent prognostic factor in patients with HCC. Overall, the results indicated that FXYD3 expression levels were higher in HCC tumor tissues than in adjacent non-cancerous tissues, and that the FXYD3 protein may serve as a prognostic marker for HCC. D.A. Spandidos 2018-03 2017-12-21 /pmc/articles/PMC5778849/ /pubmed/29435033 http://dx.doi.org/10.3892/ol.2017.7688 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Li-Juan
Li, Qi-Jiong
Le, Yong
Ouyang, Han-Yue
He, Min-Ke
Yu, Zi-Shan
Zhang, Yong-Fa
Shi, Ming
Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title_full Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title_fullStr Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title_full_unstemmed Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title_short Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma
title_sort prognostic significance of sodium-potassium atpase regulator, fxyd3, in human hepatocellular carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778849/
https://www.ncbi.nlm.nih.gov/pubmed/29435033
http://dx.doi.org/10.3892/ol.2017.7688
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