Lentivirus-mediated silencing of HOTAIR lncRNA restores gefitinib sensitivity by activating Bax/Caspase-3 and suppressing TGF-α/EGFR signaling in lung adenocarcinoma

Secondary resistance is a major limitation in the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment of lung cancer. Previous studies have shown that expression of the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is upregulated in lung cancer, which...

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Detalles Bibliográficos
Autores principales: Liu, Yuanshun, Jiang, Hua, Zhou, Hongbin, Ying, Xiwang, Wang, Zhehua, Yang, Yang, Xu, Wulin, He, Xujun, Li, Yaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778865/
https://www.ncbi.nlm.nih.gov/pubmed/29467862
http://dx.doi.org/10.3892/ol.2017.7656

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