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Common mental disorders and association with telomere length

Telomeres are repeated 5′-TTAGGG-3′ sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Ch...

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Autores principales: Vakonaki, E., Tsiminikaki, K., Plaitis, S., Fragkiadaki, P., Tsoukalas, D., Katsikantami, I., Vaki, G., Tzatzarakis, M. N., Spandidos, D. A., Tsatsakis, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778888/
https://www.ncbi.nlm.nih.gov/pubmed/29435268
http://dx.doi.org/10.3892/br.2018.1040
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author Vakonaki, E.
Tsiminikaki, K.
Plaitis, S.
Fragkiadaki, P.
Tsoukalas, D.
Katsikantami, I.
Vaki, G.
Tzatzarakis, M. N.
Spandidos, D. A.
Tsatsakis, A. M.
author_facet Vakonaki, E.
Tsiminikaki, K.
Plaitis, S.
Fragkiadaki, P.
Tsoukalas, D.
Katsikantami, I.
Vaki, G.
Tzatzarakis, M. N.
Spandidos, D. A.
Tsatsakis, A. M.
author_sort Vakonaki, E.
collection PubMed
description Telomeres are repeated 5′-TTAGGG-3′ sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress-anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment. Most studies report reduced telomere length in patients suffering from mental disorders, compared to the general population. Since the factors that can affect telomere length are various, more experiments and investigations are required to understand the general impact of different factors on telomere length.
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spelling pubmed-57788882018-02-12 Common mental disorders and association with telomere length Vakonaki, E. Tsiminikaki, K. Plaitis, S. Fragkiadaki, P. Tsoukalas, D. Katsikantami, I. Vaki, G. Tzatzarakis, M. N. Spandidos, D. A. Tsatsakis, A. M. Biomed Rep Review Telomeres are repeated 5′-TTAGGG-3′ sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress-anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment. Most studies report reduced telomere length in patients suffering from mental disorders, compared to the general population. Since the factors that can affect telomere length are various, more experiments and investigations are required to understand the general impact of different factors on telomere length. D.A. Spandidos 2018-02 2018-01-08 /pmc/articles/PMC5778888/ /pubmed/29435268 http://dx.doi.org/10.3892/br.2018.1040 Text en Copyright: © Vakonaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Vakonaki, E.
Tsiminikaki, K.
Plaitis, S.
Fragkiadaki, P.
Tsoukalas, D.
Katsikantami, I.
Vaki, G.
Tzatzarakis, M. N.
Spandidos, D. A.
Tsatsakis, A. M.
Common mental disorders and association with telomere length
title Common mental disorders and association with telomere length
title_full Common mental disorders and association with telomere length
title_fullStr Common mental disorders and association with telomere length
title_full_unstemmed Common mental disorders and association with telomere length
title_short Common mental disorders and association with telomere length
title_sort common mental disorders and association with telomere length
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778888/
https://www.ncbi.nlm.nih.gov/pubmed/29435268
http://dx.doi.org/10.3892/br.2018.1040
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