K(2P)2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site

Polymodal K(2P) (KCNK) thermo- and mechanosensitive TREK(1) potassium channels, generate ‘leak’ currents that regulate neuronal excitability, respond to lipids, temperature, and mechanical stretch, and influence pain, temperature perception, and anesthetic responses(1–3). These dimeric voltage-gated...

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Detalles Bibliográficos
Autores principales: Lolicato, Marco, Arrigoni, Cristina, Mori, Takahiro, Sekioka, Yoko, Bryant, Clifford, Clark, Kimberly A., Minor, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778891/
https://www.ncbi.nlm.nih.gov/pubmed/28693035
http://dx.doi.org/10.1038/nature22988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778891/
https://www.ncbi.nlm.nih.gov/pubmed/28693035
http://dx.doi.org/10.1038/nature22988

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