Cargando…
K(2P)2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site
Polymodal K(2P) (KCNK) thermo- and mechanosensitive TREK(1) potassium channels, generate ‘leak’ currents that regulate neuronal excitability, respond to lipids, temperature, and mechanical stretch, and influence pain, temperature perception, and anesthetic responses(1–3). These dimeric voltage-gated...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778891/ https://www.ncbi.nlm.nih.gov/pubmed/28693035 http://dx.doi.org/10.1038/nature22988 |