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Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor

The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral...

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Detalles Bibliográficos
Autores principales: Tan, Yi, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778900/
https://www.ncbi.nlm.nih.gov/pubmed/29435025
http://dx.doi.org/10.3892/ol.2017.7673
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author Tan, Yi
Li, Ping
author_facet Tan, Yi
Li, Ping
author_sort Tan, Yi
collection PubMed
description The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain. One, three, and seven days after extraction, pain, swelling, and mouth opening in the experimental group improved compared to the control group. Additionally, the levels of IL-25 and TNF-α in the experimental group were significantly lower than in the control group, suggesting less inflammatory response. On the other hand, EGFR and β-FGF were significantly higher in the experimental group, supporting the activation of tissue repair pathways. Quality of life scores were significantly better in the experimental group. Overall, bromelain improves the quality of life, alleviates pain, swelling, and mouth opening, and effectively prevent postoperative complications in patients with hematologic tumors after third molar extraction during chemotherapy.
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spelling pubmed-57789002018-02-12 Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor Tan, Yi Li, Ping Oncol Lett Articles The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain. One, three, and seven days after extraction, pain, swelling, and mouth opening in the experimental group improved compared to the control group. Additionally, the levels of IL-25 and TNF-α in the experimental group were significantly lower than in the control group, suggesting less inflammatory response. On the other hand, EGFR and β-FGF were significantly higher in the experimental group, supporting the activation of tissue repair pathways. Quality of life scores were significantly better in the experimental group. Overall, bromelain improves the quality of life, alleviates pain, swelling, and mouth opening, and effectively prevent postoperative complications in patients with hematologic tumors after third molar extraction during chemotherapy. D.A. Spandidos 2018-03 2017-12-20 /pmc/articles/PMC5778900/ /pubmed/29435025 http://dx.doi.org/10.3892/ol.2017.7673 Text en Copyright: © Tan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Tan, Yi
Li, Ping
Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title_full Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title_fullStr Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title_full_unstemmed Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title_short Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
title_sort bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778900/
https://www.ncbi.nlm.nih.gov/pubmed/29435025
http://dx.doi.org/10.3892/ol.2017.7673
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