Newly Identified NO‐Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function

BACKGROUND: Guanylyl cyclase, a heme‐containing α1β1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO‐GC1‐cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac hypertrophy–related remodeling. We recently reported that the β1 s...

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Detalles Bibliográficos
Autores principales: Crassous, Pierre‐Antoine, Shu, Ping, Huang, Can, Gordan, Richard, Brouckaert, Peter, Lampe, Paul D., Xie, Lai‐Hua, Beuve, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778997/
https://www.ncbi.nlm.nih.gov/pubmed/29269353
http://dx.doi.org/10.1161/JAHA.117.006397

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